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TU Berlin

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Structural snapshot of a bacterial phytochrome in its functional intermediate state
Zitatschlüssel ISI:000450754900007
Autor Schmidt, Andrea and Sauthof, Luisa and Szczepek, Michal and Lopez, Maria Fernandez and Escobar, Francisco Velazquez and Qureshi, Bilal M. and Michael, Norbert and Buhrke, David and Stevens, Tammo and Kwiatkowski, Dennis and Von Stetten, David and Mroginski, Maria Andrea and Krauss, Norbert and Lamparter, Tilman and Hildebrandt, Peter and Scheerer, Patrick
Jahr 2018
ISSN 2041-1723
DOI 10.1038/s41467-018-07392-7
Adresse MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Journal NATURE COMMUNICATIONS
Jahrgang 9
Monat NOV 21
Verlag NATURE PUBLISHING GROUP
Zusammenfassung Phytochromes are modular photoreceptors of plants, bacteria and fungi that use light as a source of information to regulate fundamental physiological processes. Interconversion between the active and inactive states is accomplished by a photoinduced reaction sequence which couples the sensor with the output module. However, the underlying molecular mechanism is yet not fully understood due to the lack of structural data of functionally relevant intermediate states. Here we report the crystal structure of a Meta-F intermediate state of an Agp2 variant from Agrobacterium fabrum. This intermediate, the identity of which was verified by resonance Raman spectroscopy, was formed by irradiation of the parent Pfr state and displays significant reorientations of almost all amino acids surrounding the chromophore. Structural comparisons allow identifying structural motifs that might serve as conformational switch for initiating the functional secondary structure change that is linked to the (de-)activation of these photoreceptors.
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